Can CBD oil help with chronic pain?

CBD oil comes in either topical or ingestible forms and has been studied as an alternative to opioids in the area of pain management. Research indicates that CBD oil offers relief for some patients, but not all, who are experiencing certain types of chronic pain. A review of existing research on cannabinoids and pain, published in Frontiers in Pharmacology, explains that CBD "is thought to have significant analgesic, anti-inflammatory, anti-convulsant, and anxiolytic" effects, and that it "regulates the perception of pain" by affecting a large number of receptors in the brain. 
A study of 29 patients with peripheral neuropathy (weakness, numbness, and pain from nerve damage) in their lower extremities found that topical CBD provided a "statistically significant reduction" in pain over a placebo. In contrast, a 2020 review of research on CBD's connection to pain, also published in Frontiers in Pharmacology, found that in "studies of generalized chronic pain, CBD treatment did not significantly reduce measures of pain." The authors did note, however, that "there was consistent improvement in patient-reported quality of life and quality of sleep." If this is an avenue you're interested in exploring, talk to your primary care physician before making any changes to your pain management regimen.

How we chose these products 

This list of the best CBD oils for pain relief was compiled based on personal experiences with the products, customer reviews, and in-depth research into hemp sources, potency, price, and third-party lab testing. All of the oils we recommend are high-quality and meet strict purity and safety standards.

Our CBD oil recommendations

This 100% natural CBD oil by Spruce is an extra-potent formula that may provide some comfort for individuals looking to manage chronic pain. It's organic, vegan, gluten-free, pesticide-free, and contains no artificial flavors, sweeteners, and preservatives, plus it's made in the U.S. The full-spectrum oil undergoes third-party testing to ensure proper levels of THC and potency for pain relief support.

Is CBD effective in pain management?

There are endogenous and exogenous cannabinoids. Endogenous cannabinoids are naturally occurring lipids that the body produces. Two of the most well-known endogenous cannabinoids are anandamide (AEA) and 2-arachidonoylglycerol.

The body does not produce exogenous cannabinoids — these compounds are part of the cannabis plant. Examples of exogenous cannabinoids include:

CBD
THC
cannabichromene
cannabigerol
Cannabinoids, both endogenous and exogenous, bind to endocannabinoid receptors attached to cells. These include cannabinoid 1 and cannabinoid 2 receptors. This binding action stimulates different cell responses that influence pain signaling pathways.

CBD does not bind very well to endocannabinoid receptors. However, it may interact with neurological receptors in the spinal cord that suppress chronic inflammatory pain, as one study on mice found. CBD may also strengthenTrusted Source the effects of AEA, an endogenous cannabinoid that reduces pain


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